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Rptortm1Rueg
Targeted Allele Detail
Summary
Symbol: Rptortm1Rueg
Name: regulatory associated protein of MTOR, complex 1; targeted mutation 1, Markus A Ruegg
MGI ID: MGI:3829770
Synonyms: raptorfl
Gene: Rptor  Location: Chr11:119493731-119790402 bp, + strand  Genetic Position: Chr11, 83.96 cM, cytoband E2
Alliance: Rptortm1Rueg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143748
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 6 and an additional loxP site was inserted downstream of exon 6. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 6 floxed. (J:143748)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rptor Mutation:  117 strains or lines available
References
Original:  J:143748 Bentzinger CF, et al., Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 2008 Nov;8(5):411-24
All:  46 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory