Tg(Il17f-cre)1Awai
Transgene Detail
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| Symbol: |
Tg(Il17f-cre)1Awai |
| Name: |
transgene insertion 1, Ari Waisman |
| MGI ID: |
MGI:3831089 |
| Synonyms: |
IL-17F-Cre |
| Transgene: |
Tg(Il17f-cre)1Awai Location: unknown
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| Alliance: |
Tg(Il17f-cre)1Awai page
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| Strain of Origin: |
C57BL/6 x DBA
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Il17f-cre)1Awai expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Il17f |
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Mutation details: A bacterial artificial chromosome containing the Il17f locus was used to construct a transgene vector. Exons 1 and 2 of the locus were replaced with a cre recombinase expression cassette and a neomycin selection cassette. Founder mice were obtained after injection of linearized vector into the pronuclei of fertilized eggs. When transgenic mice were crossed to mice carrying the cre-reporter allele Gt(ROSA)26Sortm1(EYFP)Cos, cre expression was detected in CD8+ T cells and, to a lesser extent, CD4+ T cells after culturing in vitro under Th17-polarizing conditions. Cre expression was also detected in vivo by CD4+ T cells after induction of experimental autoimmune encephalomyelitis.
(J:144336)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Il17f
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:144336 Croxford AL, et al., Cutting edge: An IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells. J Immunol. 2009 Feb 1;182(3):1237-41 |
| All: |
5 reference(s) |
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Analysis Tools
