Traf3ip2tm1Sbn
Targeted Allele Detail
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| Symbol: |
Traf3ip2tm1Sbn |
| Name: |
TRAF3 interacting protein 2; targeted mutation 1, Ulrich Siebenlist |
| MGI ID: |
MGI:3831153 |
| Synonyms: |
CIKS- |
| Gene: |
Traf3ip2 Location: Chr10:39488930-39531303 bp, + strand Genetic Position: Chr10, 20.86 cM
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| Alliance: |
Traf3ip2tm1Sbn page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:144320
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 3.6 Kb BamHI fragment containing exon 2 was replaced with a neomycin selection cassette. Correct targeting was confirmed by Southern blotting. Analysis of mRNAs from homozygote B cells demonstrates exon 1 was spliced to exon 3. All potential ATG start codons upstream of exon 3 and located in the correct reading frame are followed by at least 2 stop codons prior to the start of exon 3. The first ATG present within the functional reading frame downstream of the start of exon 3 is located in exon 5, which could only generate a 157 amino acid long fragment of the 555 amino acid endogenous protein. For these reasons, a functional protein product was considered unlikely.
(J:144320)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Traf3ip2 Mutation: |
41 strains or lines available
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| Original: |
J:144320 Claudio E, et al., The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol. 2009 Feb 1;182(3):1617-30 |
| All: |
14 reference(s) |
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Analysis Tools
