Results
|
Specimen
not shown:
embryonic day 13.0
(more )
Specimen
not shown:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
embryonic day 13.0
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS21: epidermis |
Weak |
Widespread |
|
Weak, cytoplasmic expression was uniformly present in the epithelial precursors of the epidermis.
|
Specimen
1A, B:
embryonic day 14.5
(more )
Specimen
1A, B:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
embryonic day 14.5
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS22: epidermis |
Weak |
|
1A
,
1B
|
|
TS22: hair follicle |
Strong |
Regionally restricted |
1B
,
1A
|
Expression becomes nuclear and abundant in epithelial cells of the developing hair follicles.
|
Specimen
1C, D:
embryonic day 16.5
(more )
Specimen
1C, D:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
embryonic day 16.5
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS24: hair follicle |
Strong |
Regionally restricted |
1D
,
1C
|
Intense nuclear staining appeared in basal cells that form the placodes.
|
Specimen
1E, F:
embryonic day 16.5
(more )
Specimen
1E, F:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
embryonic day 16.5
|
Age Note:
|
Age of embryo at noon of plug day not specified in reference.
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS24: hair follicle |
Strong |
Regionally restricted |
1E
,
1F
|
Intense nuclear staining appeared in basal cells that form the placodes.
|
Specimen
2A, B:
postnatal newborn
(more )
Note: First anagen.
Specimen
2A, B:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal newborn
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
First anagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS27: hair follicle |
Strong |
Regionally restricted |
2A
,
2B
|
Intense nuclear expression was detected in the lower segment of the follicle. In the upper segment of the folicle, expression was more faint and cytoplasmic.
|
TS27: hair outer root sheath |
Strong |
|
2A
,
2B
|
|
TS27: epidermis |
Weak |
Regionally restricted |
2B
,
2A
|
Expression was faint and cytoplasmic in the basal layer of the epidermis adjacent to the follicle.
|
Specimen
2C, D:
postnatal day 4
(more )
Note: First anagen.
Specimen
2C, D:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 4
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
First anagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Present |
Regionally restricted |
2D
,
2C
|
Expression was detected in the outer root sheath and the matrix layer immediately adjacent to the follicular papilla.
|
TS28: hair root sheath matrix |
Present |
Regionally restricted |
2D
,
2C
|
Expression was detected in the outer root sheath and the matrix layer immediately adjacent to the follicular papilla.
|
TS28: hair follicle |
Present |
Regionally restricted |
2C
,
2D
|
Staining was weaker and cytoplasmic in the upper segment of the follicle .
|
Specimen
2E, F:
postnatal day 10
(more )
Note: First anagen.
Specimen
2E, F:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 10
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
First anagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Strong |
Regionally restricted |
2E
,
2F
|
Expression was nuclear and abundant in the basal layer of the outer root sheath.
|
TS28: hair follicle |
Present |
Regionally restricted |
2F
,
2E
|
In the follicular stalk, nuclear expression was present in some suprabasal cells. Staining in the upper follicular segment was weak and cytoplasmic.
|
Specimen
2G, H:
postnatal day 10
(more )
Note: First anagen.
Specimen
2G, H:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 10
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
First anagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Strong |
Regionally restricted |
2H
,
2G
|
Expression was nuclear and abundant in the basal layer of the outer root sheath.
|
TS28: hair root sheath matrix |
Present |
Regionally restricted |
2G
,
2H
|
Expression was nuclear in both the basal layer of the matrix and a short column of epithelial cells immediately above the papilla.
|
Specimen
not shown:
postnatal day 16
(more )
Specimen
not shown:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 16
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Specimen
3A, B:
postnatal newborn
(more )
Specimen
3A, B:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal newborn
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Structure |
Level |
Pattern |
Image |
Note |
TS27: hair follicle |
Present |
|
3A
,
3B
|
Expression is cytoplasmic and weak in the upper segment of the hair follicle. Staining is nuclear and higher intensity in the lower follicle segment.
|
TS27: epidermis |
Weak |
Regionally restricted |
3B
,
3A
|
Expression was weak and cytoplasmic in the basal layer of the epidermis. Staining in the stratum corneum is non-specific.
|
Specimen
4A, B:
postnatal day 17
(more )
Note: Regressing hair follicles of the first catagen.
Specimen
4A, B:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 17
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Regressing hair follicles of the first catagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Present |
Regionally restricted |
4B
,
4A
|
Nuclear staining was detected in the outer root sheath cells surrounding the differentiating club hair.
|
TS28: hair follicle |
Present |
Regionally restricted |
4B
,
4A
|
Expression was detected in the cells of the epithelial strand connecting the presumptive club to the follicular papilla.
|
Specimen
4C, D:
postnatal day 17
(more )
Note: Regressing hair follicles of the first catagen.
Specimen
4C, D:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 17
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Regressing hair follicles of the first catagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Present |
Regionally restricted |
4D
,
4C
|
Nuclear staining was detected in the outer root sheath cells surrounding the differentiating club hair.
|
TS28: hair follicle |
Present |
Regionally restricted |
4C
,
4D
|
Expression was detected in the cells of the epithelial strand connecting the presumptive club to the follicular papilla.
|
Specimen
5A, B:
postnatal day 19
(more )
Note: Telogen follicles.
Specimen
5A, B:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 19
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Telogen follicles.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Present |
Regionally restricted |
5A
,
5B
|
Nuclear expression was detected in the outer root sheath encasing the club. Expression decreased in the outer root sheath cells near the upper end of the club.
|
TS28: hair follicle |
Present |
Regionally restricted |
5A
,
5B
|
Expression was detected in a peg beneath the club in close contact with the follicular papilla.
|
Specimen
5C, D:
postnatal day 19
(more )
Note: Telogen follicles.
Specimen
5C, D:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 19
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Telogen follicles.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Present |
Regionally restricted |
5D
,
5C
|
Nuclear expression was detected in the outer root sheath encasing the club. Expression decreased in the outer root sheath cells near the upper end of the club.
|
TS28: hair follicle |
Present |
Regionally restricted |
5C
,
5D
|
Expression was detected in a peg beneath the club in close contact with the follicular papilla.
|
Specimen
6A, B:
postnatal day 20
(more )
Note: Second cycle of hair growth - anagen.
Specimen
6A, B:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 20
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
Second cycle of hair growth - anagen.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair follicle |
Present |
Regionally restricted |
6A
,
6B
|
Nuclear expression was detected in the germ cells growing downwards into the dermis and enveloping the follicular papillae.
|
TS28: hair outer root sheath |
Trace |
|
6A
,
6B
|
|
Specimen
6C, D:
postnatal day 20
(more )
Note: New hair bulb forming.
Specimen
6C, D:
(close )
Genetic Background:
|
FVB/N
|
Age:
|
postnatal day 20
|
Sex:
|
Not Specified
|
Type:
|
section
|
Embedding:
|
Cryosection
|
Note:
|
New hair bulb forming.
|
Structure |
Level |
Pattern |
Image |
Note |
TS28: hair outer root sheath |
Present |
Regionally restricted |
6D
,
6C
|
As a new hair bulb formed, nuclear staining was detected in basal keratinocytes of the developing outer root sheath and matrix.
|
TS28: hair root sheath matrix |
Present |
Regionally restricted |
6D
,
6C
|
As a new hair bulb formed, nuclear staining was detected in basal keratinocytes of the developing outer root sheath and matrix.
|
|