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Tg(GH1-cre)1Sac
Transgene Detail
Summary
Symbol: Tg(GH1-cre)1Sac
Name: transgene insertion 1, Sally A Camper
MGI ID: MGI:3833232
Synonyms: Tg(Gh-cre)SAC1
Transgene: Tg(GH1-cre)1Sac  Location: unknown  
Alliance: Tg(GH1-cre)1Sac page
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL/J)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(GH1-cre)1Sac expression driven by 1 gene
 
Mutation details: The human growth hormone locus control region (-16.2 to -14.6 kb relative to the GH1 promoter) was fused to 1.77 kb of rat Gh1 promoter to drive expression of a cre recombinase cassette in the pituitary gland. About 30-50 copies of the transgene construct inserted into the genome after injection into zygotes. When crossed with cre-reporter strains, cre expression was observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression was also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney. (J:144723)
Structure of the Tg(GH1-cre)1Sac transgene
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: GH1 (human)
Summary of all recombinase alleles driven by GH1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:144723 Nasonkin IO, et al., Cre-mediated recombination in pituitary somatotropes. Genesis. 2009 Jan;47(1):55-60
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory