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Cdk6tm1Phin
Targeted Allele Detail
Summary
Symbol: Cdk6tm1Phin
Name: cyclin dependent kinase 6; targeted mutation 1, Philip Hinds
MGI ID: MGI:3833563
Synonyms: Cdk6-LSL
Gene: Cdk6  Location: Chr5:3391485-3581008 bp, + strand  Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
Alliance: Cdk6tm1Phin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144975
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
 
Mutation details: A floxed STOP cassette flanked by splice acceptor sites was inserted downstream of exon 1. Presence of the STOP cassette prevents expression of the gene as confirmed by western blot analysis on thymocyte extracts. (J:144975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk6 Mutation:  40 strains or lines available
References
Original:  J:144975 Hu MG, et al., A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res. 2009 Feb 1;69(3):810-8
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory