Atxn3tm1Isch
Targeted Allele Detail
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| Symbol: |
Atxn3tm1Isch |
| Name: |
ataxin 3; targeted mutation 1, Ina Schmitt |
| MGI ID: |
MGI:3833681 |
| Gene: |
Atxn3 Location: Chr12:101885160-101924505 bp, - strand Genetic Position: Chr12, 51.32 cM
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| Alliance: |
Atxn3tm1Isch page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:145048
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced part of exon 2 and all of exons 3-5. If splicing were to occur, the resulting mRNA would encode only the first 23 codons and an out of frame codon followed by a stop codon. Loss of protein expression was confirmed by immunoblot analysis. Many mice in this colony are heterozygous for a 365 kb deletion between positions 60.976 and 61.341 Mb of chromosome 6. Since this mutation is on chromosome 12, it should be possible to breed it away from the chromosome 6 deletion.
(J:145048)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Atxn3 Mutation: |
48 strains or lines available
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| Original: |
J:145048 Schmitt I, et al., Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem Biophys Res Commun. 2007 Oct 26;362(3):734-9 |
| All: |
3 reference(s) |
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Analysis Tools
