Baiap2<Gt(XG757)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3835373)

Baiap2^Gt(XG757)Byg
Gene trapped Allele Detail

Summary

Symbol:	Baiap2^Gt(XG757)Byg
Name:	brain-specific angiogenesis inhibitor 1-associated protein 2; gene trap XG757, BayGenomics
MGI ID:	MGI:3835373
Synonyms:	IRSp53^-
Gene:	Baiap2 Location: Chr11:119833762-119897608 bp, + strand Genetic Position: Chr11, 83.96 cM, cytoband E2
Alliance:	Baiap2^Gt(XG757)Byg page

Mutation
origin

Mutant Cell Line:	XG757
Germline Transmission:	Earliest citation of germline transmission: J:144939
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap

Mutation details: A gene trap vector containing the En2 splice acceptor upstream of the beta-geo (lacZ-neomycin) gene and a polyadenylation signal was inserted into the intron between exons 3 and 4 of the gene. Absence of protein expression was confirmed in homozyous mice total brain homogenate by Western blot. (J:144939)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	138 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Baiap2 Mutation:	29 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:144939 Kim MH, et al., Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. J Neurosci. 2009 Feb 4;29(5):1586-95
All:	10 reference(s)

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