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Tg(Cdh5-cre)1Spe
Transgene Detail
Summary
Symbol: Tg(Cdh5-cre)1Spe
Name: transgene insertion 1, Nancy A Speck
MGI ID: MGI:3836418
Synonyms: Cdh5-cre, VECad-Cre, VEC-Cre
Transgene: Tg(Cdh5-cre)1Spe  Location: unknown  
Alliance: Tg(Cdh5-cre)1Spe page
Transgene
origin
Strain of Origin:  (C57BL/6J x 129S1/SvImJ)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Cdh5-cre)1Spe expression driven by 1 gene
 
Mutation details: 2.5 Kb of the Cdh5 promoter was fused to a cre recombinase gene and placed between two genomic insulators derived from the chicken gamma-globulin gene. When crossed with cre-reporter strains, cre expression was detected in the yolk sac and vasculature of E9.5-E10.5 conceptus, and in the liver of E15.5 fetuses. Nearly all adult blood cells from mice carrying this transgene are derived from progentiors that have expressed cre. (J:145700)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdh5 (species not specified)
Summary of all recombinase alleles driven by Cdh5.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
3 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:145700 Chen MJ, et al., Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature. 2009 Feb 12;457(7231):887-91
All:  65 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory