About   Help   FAQ
Tg(Tek-icre/ERT2)1Soff
Transgene Detail
Summary
Symbol: Tg(Tek-icre/ERT2)1Soff
Name: transgene insertion 1, Stefan Offermanns
MGI ID: MGI:3837451
Synonyms: tie2-CreERT2
Transgene: Tg(Tek-icre/ERT2)1Soff  Location: unknown  
Alliance: Tg(Tek-icre/ERT2)1Soff page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Tek-icre/ERT2)1Soff expression driven by 1 gene
 
Mutation details: A tamoxifen-inducible icre recombinase gene and FRT-flanked beta-lactamase gene were inserted into the ATG start site of the murine Tek gene located on a BAC. After Flpe-mediated excision of the beta-lactamase gene, the targeted BAC was injected into FVB/N oocytes. Cre expression was detected in endothelial cells of numerous organs after treatment with tamoxifen. (J:146132)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tek (mouse)
Summary of all recombinase alleles driven by Tek.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:146132 Korhonen H, et al., Anaphylactic shock depends on endothelial Gq/G11. J Exp Med. 2009 Feb 16;206(2):411-20
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory