Ttrtm2(TTR)Kymm
Targeted Allele Detail
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| Symbol: |
Ttrtm2(TTR)Kymm |
| Name: |
transthyretin; targeted mutation 2, Ken-ichi Yamamura |
| MGI ID: |
MGI:3838182 |
| Synonyms: |
I(-)P(+), TtrhTTRVal30, TTRVAL30 |
| Gene: |
Ttr Location: Chr18:20798337-20807378 bp, + strand Genetic Position: Chr18, 11.47 cM
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| Alliance: |
Ttrtm2(TTR)Kymm page
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| Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, RMCE-ready) |
| Mutations: |
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Insertion, Intragenic deletion
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Ttrtm2(TTR)Kymm expresses
1 gene
Knock-in expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TTR (7276) |
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Mutation details: ES cells containing the Ttrtm1Kymm null allele that serves as acceptor in recombination mediated cassette exchange were electroporated with a replacement vector and a cre recombinase expression vector. The replacement vector consisted of a wild-type human TTR cDNA and a FRT-flanked puromycin resistance gene flanked by a lox66 and a loxP site. Northern blot analysis indicated gene expression in the brain, liver and eye of homozygote mice was similar to endogenous expression in wild-type mice. Human but not mouse TTR protein was detected in the liver and serum of homozygote mice in immunoblot assays.
(J:146510)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ttr Mutation: |
46 strains or lines available
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| Original: |
J:146510 Zhao G, et al., Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus. Genes Cells. 2008 Nov 13;13(12):1257-1268 |
| All: |
4 reference(s) |
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Analysis Tools
