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Heg1tm1Mlkn
Targeted Allele Detail
Summary
Symbol: Heg1tm1Mlkn
Name: heart development protein with EGF-like domains 1; targeted mutation 1, Mark L Kahn
MGI ID: MGI:3838392
Gene: Heg1  Location: Chr16:33504754-33591946 bp, + strand  Genetic Position: Chr16, 24.17 cM
Alliance: Heg1tm1Mlkn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:146528
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1 was replaced with a LacZ gene and neo cassette via homologous recombination. RT-PCR confirmed the absence of RNA expression in homozygous embryos. (J:146528)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Heg1 Mutation:  56 strains or lines available
References
Original:  J:146528 Kleaveland B, et al., Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb;15(2):169-76
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory