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Bcl11btm1.2Leid
Targeted Allele Detail
Summary
Symbol: Bcl11btm1.2Leid
Name: B cell leukemia/lymphoma 11B; targeted mutation 1.2, Mark Leid
MGI ID: MGI:3839578
Synonyms: CTIP2-, CTIP2L-
Gene: Bcl11b  Location: Chr12:107876662-107969861 bp, - strand  Genetic Position: Chr12, 59.1 cM, cytoband F1
Alliance: Bcl11btm1.2Leid page
Defects in tooth development in Bcl11btm1.2Leid/Bcl11btm1.2Leid mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147182
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A loxP site was inserted upstream of exon 4 and an frt flanked neo cassette and a second loxP site were inserted downstream of exon 4 via homologous recombination. Exon 4 was then removed via Cre mediated recombination. Immunoblot analysis confirmed the absence of protein expression in the skin of homozygous mice. (J:147182)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 101 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl11b Mutation:  46 strains or lines available
References
Original:  J:147182 Golonzhka O, et al., Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol. 2009 Jun;129(6):1459-70
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory