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Gbx2tm1.1(cre/ERT2)Jyhl
Targeted Allele Detail
Summary
Symbol: Gbx2tm1.1(cre/ERT2)Jyhl
Name: gastrulation brain homeobox 2; targeted mutation 1.1, James Y H Li
MGI ID: MGI:3840448
Synonyms: Gbx2CreER, Gbx2CreER-ires-eGFP
Gene: Gbx2  Location: Chr1:89855684-89858898 bp, - strand  Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
Alliance: Gbx2tm1.1(cre/ERT2)Jyhl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147282
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gbx2tm1.1(cre/ERT2)Jyhl expression driven by 1 gene
 
Mutation details: A cre/ERT2-IRES-EGFP-frt flanked neo cassette was inserted into the 5' untranslated region via homologous recombination. The neo cassette was then removed by Flp mediated recombination. Expression patterns of cre/ERT2 transcripts and EGFP proteins match those of the endogenous protein. (J:147282)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gbx2 (mouse)
Summary of all recombinase alleles driven by Gbx2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gbx2 Mutation:  27 strains or lines available
References
Original:  J:147282 Chen L, et al., Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development. 2009 Apr;136(8):1317-26
All:  36 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory