Asxl2Gt(AQ0356)Wtsi
Gene trapped Allele Detail
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| Symbol: |
Asxl2Gt(AQ0356)Wtsi |
| Name: |
ASXL transcriptional regulator 2; gene trap AQ0356, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:3840841 |
| Gene: |
Asxl2 Location: Chr12:3476857-3556852 bp, + strand Genetic Position: Chr12, 1.81 cM
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| Alliance: |
Asxl2Gt(AQ0356)Wtsi page
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Axial skeleton patterning is disrupted in Asxl2Gt(AQ0356)Wtsi/Asxl2Gt(AQ0356)Wtsi mice
Show the 2 phenotype image(s) involving this allele.
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| Mutant Cell Line: |
AQ0356 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:147372
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| Parent Cell Line: |
E14TG2a.4 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Project Collection: |
Sanger Inst. Gene Trap Res.
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| Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
| Mutation: |
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Insertion of gene trap vector
Vector: pGT0lxr
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Mutation details: The gene trap vector was inserted 5016 bp downstream of exon 1. RT-PCR confirmed the expression of an fusion transcript between exon 1 and the gene trap vector. Real time PCR detected expression of wild type transcript in hearts from homozygous mice at about 3% of the level seen in wild-type hearts. LacZ expression was detected in the developing heart, axial skeleton, neocortex, spinal cord, and eye. Postnatally expression was seen in the heart, retina, ovary and testis.
(J:147372)
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| Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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| Genome Context: |
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Genome Browser view of this mutation
84 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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Generation of the Asxl2Gt(AQ0356)Wtsi allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Asxl2 Mutation: |
126 strains or lines available
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| Original: |
J:147372 Baskind HA, et al., Functional conservation of asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene asx. PLoS One. 2009;4(3):e4750 |
| All: |
8 reference(s) |
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Analysis Tools
