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Gnmttm1Ymac
Targeted Allele Detail
Summary
Symbol: Gnmttm1Ymac
Name: glycine N-methyltransferase; targeted mutation 1, Yi-Ming Arthur Chen
MGI ID: MGI:3842652
Gene: Gnmt  Location: Chr17:47036590-47040091 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband C
Alliance: Gnmttm1Ymac page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147857
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 1 through 4 and part of exon 5 were replaced with a neo cassette. The absence of protein was confirmed by western blot analysis on hepatic lysate. (J:147857)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 66 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnmt Mutation:  25 strains or lines available
References
Original:  J:147857 Liu SP, et al., Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007 Nov;46(5):1413-25
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory