Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Ihhtm1.1Dcha
Name:	Indian hedgehog; targeted mutation 1.1, Danny Chan
MGI ID:	MGI:3842979
Synonyms:	IhhE95K
Gene:	Ihh  Location: Chr1:74984474-74990831 bp, - strand  Genetic Position: Chr1, 38.55 cM
Alliance:	Ihhtm1.1Dcha page

Germline Transmission:	Earliest citation of germline transmission: J:147878
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: A 397G>A substitution was introduced into exon 1 and a floxed neo cassette was inserted into intron 1 via homologous recombination. Cre mediated recombination then removed the neo cassette leaving a single loxP site in intron 1. The point mutation results in a E95K mutation in the protein. (J:147878)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ihh Mutation:	22 strains or lines available

Original:	J:147878 Gao B, et al., A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature. 2009 Apr 30;458(7242):1196-200
All:	3 reference(s)