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Egr3tm1(cre)Mod
Targeted Allele Detail
Summary
Symbol: Egr3tm1(cre)Mod
Name: early growth response 3; targeted mutation 1, Michael J O'Donovan
MGI ID: MGI:3843775
Synonyms: Egr3CRE, Egr3CRE
Gene: Egr3  Location: Chr14:70314766-70320062 bp, + strand  Genetic Position: Chr14, 36.2 cM, cytoband D1
Alliance: Egr3tm1(cre)Mod page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147957
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Egr3tm1(cre)Mod expression driven by 1 gene
 
Mutation details: The targeting construct was designed to insert an IRES-Cre-pA cassette in the 3' UTR of the Egr3 gene. Electroporation of the targeting vector into W9.5 ES cells. Clones were analyzed for homologous recombination, and positive clones were injected into C57BL/6 blastocysts to generate chimeric founders. This allele preserves expression of the endogenous Egr3 gene and expresses cre under control of the Egr3 promoter. (J:147957)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Egr3 (mouse)
Summary of all recombinase alleles driven by Egr3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr3 Mutation:  17 strains or lines available
References
Original:  J:147957 Shneider NA, et al., Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3. J Neurosci. 2009 Apr 15;29(15):4719-35
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory