Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Six2tm1(tTA,tetO-EGFP/cre)Amc
Name:	sine oculis-related homeobox 2; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:3845218
Synonyms:	Six2Cre, Six2Tet-off-eGFPCre, Six2-TGC, Six2TGC
Gene:	Six2  Location: Chr17:85991705-85995702 bp, - strand  Genetic Position: Chr17, 55.72 cM
Alliance:	Six2tm1(tTA,tetO-EGFP/cre)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:148455
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	(129/Sv x C57BL/6J)F1

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter, Transactivator) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Six2tm1(tTA,tetO-EGFP/cre)Amc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Six2 (MGI:102778)   Mutation details: A targeting vector was designed to insert a Tet-off-eGFPCre and frt-flanked PGKneobpA selection cassette into the initiation codon of the Six2 (sine oculis-related homeobox 2 homolog (Drosophila)) targeted gene. (J:148455)

Activity:	Tissue activity of this recombinase allele
Driver:	Six2 (mouse) Summary of all recombinase alleles driven by Six2. Alliance mouse Six2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Six2tm1(tTA,tetO-EGFP/cre)Amc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six2 Mutation:	16 strains or lines available

Original:	J:148455 Kobayashi A, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7;3(2):169-81
All:	23 reference(s)