Fat4tm1Hmc
Targeted Allele Detail
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| Symbol: |
Fat4tm1Hmc |
| Name: |
FAT atypical cadherin 4; targeted mutation 1, Helen McNeill |
| MGI ID: |
MGI:3846572 |
| Synonyms: |
Fat42E11 |
| Gene: |
Fat4 Location: Chr3:38941089-39066134 bp, + strand Genetic Position: Chr3, 18.72 cM
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| Alliance: |
Fat4tm1Hmc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:138247
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| Parent Cell Line: |
GK129 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and frt flanked PGK-neo cassette were inserted downstream of exon 3 via homologous recombination. Two mutant ES cell lines acquired the two loxP insertion in the targeted gene. This allele is derived from line 2E11 in which targeting occured as expected.
(J:138247)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fat4 Mutation: |
224 strains or lines available
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ES cell line = 129/1, a subline of GK129.
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| Original: |
J:138247 Saburi S, et al., Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008 Aug;40(8):1010-5 |
| All: |
10 reference(s) |
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Analysis Tools
