Fat4<tm1.1Hmc> Targeted Allele Detail MGI Mouse (MGI:3846573)

Fat4^tm1.1Hmc
Targeted Allele Detail

Summary

Symbol:	Fat4^tm1.1Hmc
Name:	FAT atypical cadherin 4; targeted mutation 1.1, Helen McNeill
MGI ID:	MGI:3846573
Synonyms:	Fat4^-, Fat4^{2E11 deltaflox}
Gene:	Fat4 Location: Chr3:38941089-39066134 bp, + strand Genetic Position: Chr3, 18.72 cM
Alliance:	Fat4^tm1.1Hmc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:138247
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and frt flanked PGK-neo cassette were inserted downstream of exon 3 via homologous recombination. Two mutant ES cell lines acquired the two loxP insertion in the targeted gene. This allele is derived from line 2E11 in which targeting occured as expected. Subsequent Cre mediated recombination removed exon 3. (J:138247)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Fat4 Mutation:	224 strains or lines available

Notes

ES cell line = 129/1, a subline of GK129.

References

Original:	J:138247 Saburi S, et al., Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008 Aug;40(8):1010-5
All:	17 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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