Tg(CMV-Atoh1,-lacZ)1Kag
Transgene Detail
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| Symbol: |
Tg(CMV-Atoh1,-lacZ)1Kag |
| Name: |
transgene insertion 1, Ryoichiro Kageyama |
| MGI ID: |
MGI:3847253 |
| Synonyms: |
M1Z-Tg1 |
| Transgene: |
Tg(CMV-Atoh1,-lacZ)1Kag Location: unknown
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| Alliance: |
Tg(CMV-Atoh1,-lacZ)1Kag page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CMV-Atoh1,-lacZ)1Kag expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Atoh1 (MGI:104654) |
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Mutation details: The transgenic construct has the mouse Atoh1 gene under control of the CMV promoter. A lox-stop-lox cassette was inserted between the CMV promoter and the Atoh1 gene in the vector. An IRES-lacZ cassette was ligated downstream of the Atoh1 sequence to monitor Atoh1 expression. (Transgenic mice were generated by DNX Biotherapeutics, Inc (NJ, USA)). Two transgenic lines, M!Z-Tg1 and M1Z-Tg2, were established. No ectopic expression of Atoh1 was detected in the absence of Cre recombination to delete the stop cassette. M1Z transgenics appeared morphologically normal and both lines showed identical phenotypes when crossed to cre-expressing animals.
(J:56248)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:56248 Isaka F, et al., Ectopic expression of the bHLH gene Math1 disturbs neural development. Eur J Neurosci. 1999 Jul;11(7):2582-8 |
| All: |
1 reference(s) |
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