Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Tg(Cdh5-cre/ERT2)1Rha Name: transgene insertion 1, Ralf H Adams MGI ID: MGI:3848982 Synonyms: Cdh5-CreER, Cdh5(PAC)-CreERT2, Tg:VE-cadherin-(PAC)CreERT2, VE-cad::CreER, VeCadCreERT, VE-Cadherin-Cre-ERT, VE-Cadherin(PAC)-CreERT2 Transgene: Tg(Cdh5-cre/ERT2)1Rha  Location: unknown   Alliance: Tg(Cdh5-cre/ERT2)1Rha page

Reduced inflammation in aortic roots obtained from tamoxifen-treated, high-fat diet fed Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw mice. Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Cdh5-cre/ERT2)1Rha expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Cdh5   Mutation details: The tamoxifen-inducible cre/ERT2 sequence was inserted into a PAC (P1 artificial chromosome) containing the VE-cadherin (Cdh5) gene to generate the transgene construct. (J:148902)

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (species not specified) Summary of all recombinase alleles driven by Cdh5. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results

List all tumor models in MMHCdb carrying Tg(Cdh5-cre/ERT2)1Rha

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available

Original:	J:148902 Sorensen I, et al., DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009 May 28;113(22):5680-8
All:	589 reference(s)