Gpr68<tm1.1Yaxu> Targeted Allele Detail MGI Mouse (MGI:3849457)

Gpr68^tm1.1Yaxu
Targeted Allele Detail

Summary

Symbol:	Gpr68^tm1.1Yaxu
Name:	G protein-coupled receptor 68; targeted mutation 1.1, Yan Xu
MGI ID:	MGI:3849457
Synonyms:	OGR1^-
Gene:	Gpr68 Location: Chr12:100842941-100874457 bp, - strand Genetic Position: Chr12, 51.1 cM
Alliance:	Gpr68^tm1.1Yaxu page

Brown adipose tissue abnormality in Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu mice compared to Gpr68^tm1Yaxu/Gpr68^tm1Yaxu mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:149315
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Germ line, cre mediated recombination removed the open reading frame. The absence of transcript expression was confirmed by RT-PCR on numerous tissue extracts. (J:149315)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gpr68 Mutation:	25 strains or lines available

References

Original:	J:149315 Li H, et al., Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One. 2009;4(5):e5705
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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