About   Help   FAQ
Tg(Rr141-cre)1Ksec
Transgene Detail
Summary
Symbol: Tg(Rr141-cre)1Ksec
Name: transgene insertion 1, Katheryn S E Cheah
MGI ID: MGI:3849597
Synonyms: B2-r4-Cre, Tg(Hoxb2-cre)1Ksec
Transgene: Tg(Rr141-cre)1Ksec  Location: unknown  
Alliance: Tg(Rr141-cre)1Ksec page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Rr141-cre)1Ksec expression driven by 1 gene
 
Mutation details: The 3.4 kb transgene construct contained a 1.4 kb genomic fragment containing murine Hoxb2 rhombomere 4 (r4) enhancer Rr141 inserted upstream of the beta-globin promoter to drive expression of cre cDNA with a nuclear localization signal (NLS). Five founder lines were generated. Line 5 showed mosaic expression when crossed to R26R reporter animals, while the remaining 4 recapitulated the Hoxb2-r4 expression pattern as reported previously. Lines 3 and 4 showed higher background staining while line 1 showed stronger cre activity than line 2. Line 1 was used for subsequent analyses. (J:149900)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxb2 (mouse)
Summary of all recombinase alleles driven by Hoxb2.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:149900 Szeto IY, et al., Utility of HoxB2 enhancer-mediated Cre activity for functional studies in the developing inner ear. Genesis. 2009 Jun;47(6):361-5
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory