Tg(Wfs1-cre/ERT2)2Aibs
Transgene Detail
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| Symbol: |
Tg(Wfs1-cre/ERT2)2Aibs |
| Name: |
transgene insertion 2, Ed Lein |
| MGI ID: |
MGI:3850189 |
| Synonyms: |
Wfs1-Tg2-CreERT2 |
| Transgene: |
Tg(Wfs1-cre/ERT2)2Aibs Location: unknown
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| Alliance: |
Tg(Wfs1-cre/ERT2)2Aibs page
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Wfs1-cre/ERT2)2Aibs expression driven by
1 gene
Transgene expression driven by:
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Mutation details: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405O19, containing the entire Wsf1 locus (and other genes), was modified by targeting a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Wsf1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. The resulting modified BAC was microinjected into embryos from B6C3 mice ((C57BL/6 x C3H)F1 X C57BL/6).
(J:146821, J:155793)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Wfs1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:155793 Madisen L, et al., A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010 Jan;13(1):133-40 |
| All: |
9 reference(s) |
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Analysis Tools
