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Stk39tm1Dlp
Targeted Allele Detail
Summary
Symbol: Stk39tm1Dlp
Name: serine/threonine kinase 39; targeted mutation 1, Eric Delpire
MGI ID: MGI:3851398
Gene: Stk39  Location: Chr2:68040789-68302381 bp, - strand  Genetic Position: Chr2, 39.53 cM, cytoband C3
Alliance: Stk39tm1Dlp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150513
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A cassette, containing tyrosinase, floxed 5' Hprt, and neo genes along with an additional copy of exon 6, was inserted downstream of exon 6. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:150513)
Generation of the Stk39tm1Dlp allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 48 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk39 Mutation:  42 strains or lines available
References
Original:  J:150513 Geng Y, et al., The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. J Biol Chem. 2009 May 22;284(21):14020-8
All:  20 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory