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Gene Expression Data
Assay Details
Assay
Reference: J:144618 Weichenhan D, et al., A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Mamm Genome. 2008 Dec;19(10-12):675-86
Assay type: RNA in situ
MGI Accession ID: MGI:3851416
Gene symbol: Cntnap5b
Gene name: contactin associated protein-like 5B
Probe: Caspr5-2 is2
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Beta-galactosidase
Assay notes: The authors state that qualitatively similar results were obtained with the other oligo probes: Caspr5-2 is1 (MGI:3851354) or Caspr5-2 is3 (MGI:3851356). The probe used in this assay was 3' labelled.
Results
Specimen 6A,B: embryonic day 15.5 (more )
Note: (B) is a higher magnification of the head are shown in (A)
Structure Level Pattern Image Note
TS23: hindbrain Present Non-Uniform 6A WT Caspr5-2 , 6B Expression is weak at the isthmus.
TS23: midbrain Present Non-Uniform 6A WT Caspr5-2 , 6B Expression is weak at the isthmus.
TS23: cerebral cortex Strong 6A WT Caspr5-2 , 6B
TS23: cortical plate Strong 6A WT Caspr5-2 , 6B
TS23: forebrain Strong 6A WT Caspr5-2 , 6B
TS23: hypothalamus Strong 6A WT Caspr5-2 , 6B
TS23: tectum Strong 6A WT Caspr5-2 , 6B
TS23: hippocampus Weak 6B , 6A WT Caspr5-2
TS23: medulla oblongata Weak 6B , 6A WT Caspr5-2
TS23: midbrain tegmentum Weak 6B , 6A WT Caspr5-2
TS23: spinal cord Weak 6B , 6A WT Caspr5-2
Specimen 6C: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 6C Caspr5-2
TS28: cortical layer II Strong 6C Caspr5-2
TS28: cortical layer III Strong 6C Caspr5-2
TS28: main olfactory bulb granule cell layer Strong 6C Caspr5-2
TS28: hippocampus Strong Regionally restricted 6C Caspr5-2 Expression is in the three major subregions of the hippocampus.
TS28: main olfactory bulb glomerular layer Strong Regionally restricted 6C Caspr5-2 Expression is in the periglomerular layer.
TS28: corpus striatum Weak 6C Caspr5-2
TS28: cortical layer I Weak 6C Caspr5-2
TS28: cortical layer IV Weak 6C Caspr5-2
TS28: cortical layer V Weak 6C Caspr5-2
TS28: cortical layer VI Weak 6C Caspr5-2
TS28: thalamus Weak 6C Caspr5-2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory