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Tg(Adora2a-cre)2MDkde
Transgene Detail
Summary
Symbol: Tg(Adora2a-cre)2MDkde
Name: transgene insertion 2M, Alban de Kerhcove d'Exaerde
MGI ID: MGI:3852493
Synonyms: A2a-cre, Adora2a-cre
Transgene: Tg(Adora2a-cre)2MDkde  Location: unknown  
Alliance: Tg(Adora2a-cre)2MDkde page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Adora2a-cre)2MDkde expression driven by 1 gene
 
Mutation details: A BAC clone of >160kb from a CJ7/129Sv Mouse BAC library (Invitrogen, formerly Genome Systems Inc.) containing the two exons of Adora2a, flanked by at least 70 kb of Adora2a 5' upstream sequences. This A2AR BAC was modified by homologous recombination in bacteria to replace the sequence of exon 1 (after the ATG transcription start site) with the cre recombinase coding sequence including 3 STOP codons. The purified BAC construct was injected into fertilized B6SJLF1 zygotes. Two founder lines, 2M and 9F, wer established. Mice were crossed to Rosa26-lacZ reporter mice to analyze cre-mediated recombination. Line 2M was used for further studies. (J:150475)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Adora2a (mouse)
Summary of all recombinase alleles driven by Adora2a.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:150475 Durieux PF, et al., D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat Neurosci. 2009 Apr;12(4):393-5
All:  25 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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