Lrig2<Gt(RST656)Byg> Gene trapped Allele Detail MGI Mouse (MGI:4128231)

Lrig2^{Gt(RST656)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Lrig2^{Gt(RST656)Byg}
Name:	leucine-rich repeats and immunoglobulin-like domains 2; gene trap RST656, BayGenomics
MGI ID:	MGI:4128231
Gene:	Lrig2 Location: Chr3:104361296-104419251 bp, - strand Genetic Position: Chr3, 45.62 cM
Alliance:	Lrig2^{Gt(RST656)Byg} page

Mutation
origin

Mutant Cell Line:	RST656
Germline Transmission:	Earliest citation of germline transmission: J:202451
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0TMpfs Vector Type: secretory trap

Mutation details: The gene trap vector inserted in intron 11 and is predicted to result in a protein fusion to the 15th extracellular leucine rich repeat of the ectodomain. Western blot and immunoblot analysis indicated that protein levels are severely reduced in embryonic lysates from homozygous mice. (J:202451)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

105 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lrig2 Mutation:	75 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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