Tet1<Gt(RRG140)Byg> Gene trapped Allele Detail MGI Mouse (MGI:4129024)

Tet1^{Gt(RRG140)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Tet1^{Gt(RRG140)Byg}
Name:	tet methylcytosine dioxygenase 1; gene trap RRG140, BayGenomics
MGI ID:	MGI:4129024
Synonyms:	Tet1^Gt
Gene:	Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
Alliance:	Tet1^{Gt(RRG140)Byg} page

Mutation
origin

Mutant Cell Line:	RRG140
Germline Transmission:	Earliest citation of germline transmission: J:194101
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap

Mutation details: Three copies of the beta-geo gene trap inserted in tandem between exon 1 and 2. Western blot analysis confirmed the absence of full-length protein in ES cells. A truncated protein is expressed. (J:194101, J:243754)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	55 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tet1 Mutation:	143 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

Initially, two copies of the gene trap were detected (J:194101). Sequencent analysis detected three copies of the gene trap (J:243754).

References

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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