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Tg(Smad7-cre)1Sjc
Transgene Detail
Summary
Symbol: Tg(Smad7-cre)1Sjc
Name: transgene insertion 1, Simon J Conway
MGI ID: MGI:4352679
Synonyms: Smad7Cre
Transgene: Tg(Smad7-cre)1Sjc  Location: unknown  
Alliance: Tg(Smad7-cre)1Sjc page
Cardiovascular abnormalities in Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+ Tg(Smad7-cre)1Sjc/0 embryos

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C3HeB/FeJ
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Smad7-cre)1Sjc expression driven by 1 gene
 
Mutation details: A 4.3 kb fragment of the Smad7 promoter was cloned into an expression vector in front of the EGFPcre sequence. The linearized construct was injected into C3H/FeJ zygotes. Two lines were generated that gave similar expression patterns when crossed to the R26R reporter line, and only one line was studied further. (J:150864)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Smad7 (species not specified)
Summary of all recombinase alleles driven by Smad7.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:150864 Snider P, et al., Generation of Smad7(-Cre) recombinase mice: A useful tool for the study of epithelial-mesenchymal transformation within the embryonic heart. Genesis. 2009 Jul;47(7):469-75
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory