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Antxr2tm1.2Lepp
Targeted Allele Detail
Summary
Symbol: Antxr2tm1.2Lepp
Name: anthrax toxin receptor 2; targeted mutation 1.2, Stephen H Leppla
MGI ID: MGI:4352944
Synonyms: CMG2-
Gene: Antxr2  Location: Chr5:98032547-98178876 bp, - strand  Genetic Position: Chr5, 47.77 cM, cytoband E3
Alliance: Antxr2tm1.2Lepp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150952
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A loxP site was inserted upstream of exon 12, which encodes the transmembrane domain, and an frt flanked neo cassette and second loxP site were inserted downstream of exon 12. Cre mediated recombination then removed exon 12 and (when present) the neo cassette leaving behind a single loxP site. (J:150952)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Antxr2 Mutation:  43 strains or lines available
References
Original:  J:150952 Liu S, et al., Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory