Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde
Name:	transgene insertion 10B, Benoit Van den Eynde
MGI ID:	MGI:4354013
Synonyms:	Tg(Tyr-cre/ESR1*,-Hras1*,-Trap1a)10BJvde, TiRP-10B
Transgene:	Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde  Location: unknown
Alliance:	Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Conditional ready, Inducible, Inserted expressed sequence, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Hras (MGI:96224) mouse Trap1a (MGI:98818)   Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Tyr (MGI:98880)   Mutation details: The mouse promoter was used to drive tamoxifen-inducible, melanocyte-specific expression of a floxed cre/ESR1 fusion containing the aminoacid substitution G521R followed out of frame by a constitutively active Hras1 with the G12V amino acid substitution, an IRES, and the mouse cDNA for Trap1a with its polyadenylation signal. Removal of the floxed cre/ERT fusion is required to express downstream genes. Eight founders were generated (TiRP-1-5, TiRP-5-6, TiRP-8/9A, TiRP-8/9B, TiRP-10A, TiRP-10B, TiRP-14 , and TiRP-16) and each contained concatemers of the transgene in head to tail or tail to tail orientations. Cre mediated recombination removes all but one copy of the recombined transgene. Activity for this line is greater in melanocytes in the hair bulbs and is not seen in the brain, eye, spleen, thymus, kidney, liver, heart, or lung. (J:107175)

Activity:	Tissue activity of this recombinase allele
Driver:	Tyr (mouse) Summary of all recombinase alleles driven by Tyr. Comparative matrix view of recombinase activities Alliance mouse Tyr gene page

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:107175 Huijbers IJ, et al., An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res. 2006 Mar 15;66(6):3278-86
All:	6 reference(s)