Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde
Transgene Detail
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| Symbol: |
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde |
| Name: |
transgene insertion 14, Benoit Van den Eynde |
| MGI ID: |
MGI:4354014 |
| Synonyms: |
Tg(Tyr-cre/ESR1*,-Hras1*,-Trap1a)14Jvde, TiRP-14 |
| Transgene: |
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde Location: unknown
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| Alliance: |
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde page
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| Transgene Type: |
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Transgenic (Conditional ready, Inducible, Inserted expressed sequence, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)14Jvde expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Tyr (MGI:98880) |
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Mutation details: The mouse promoter was used to drive tamoxifen-inducible, melanocyte-specific expression of a floxed cre/ESR1 fusion containing the aminoacid substitution G521R followed out of frame by a constitutively active Hras1 with the G12V amino acid substitution, an IRES, and the mouse cDNA for Trap1a with its polyadenylation signal. Removal of the floxed cre/ERT fusion is required to express downstream genes. Eight founders were generated (TiRP-1-5, TiRP-5-6, TiRP-8/9A, TiRP-8/9B, TiRP-10A, TiRP-10B, TiRP-14 , and TiRP-16) and each contained concatemers of the transgene in head to tail or tail to tail orientations. Cre mediated recombination removes all but one copy of the recombined transgene. In the case of line 14, cre mediated recombination also results in the removal of the polyadenylation site following Trap1a.
(J:107175)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Tyr
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:107175 Huijbers IJ, et al., An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res. 2006 Mar 15;66(6):3278-86 |
| All: |
1 reference(s) |
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Analysis Tools
