Tg(Hoxb7-cre)1Jpa
Transgene Detail
|
|
| Symbol: |
Tg(Hoxb7-cre)1Jpa |
| Name: |
transgene insertion 1, Juha Partanen |
| MGI ID: |
MGI:4354304 |
| Synonyms: |
MHB-cre |
| Transgene: |
Tg(Hoxb7-cre)1Jpa Location: unknown
|
| Alliance: |
Tg(Hoxb7-cre)1Jpa page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Tg(Hoxb7-cre)1Jpa expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Hoxb7 |
|
|
| |
|
Mutation details: The Hoxb7 promoter fragment from -1316 to +8 bp from the translation initiation codon into the CORE expression vector containing a cDNA encoding the reverse tetracycline-responsive transactivator (rtTA) sequence upstream of cDNA encoding cre recombinase controlled by a CMV minimal promoter linked to the tet operator (tetO) sequence. The construct was injected into the male pronucleus of fertilized oocytes. Eight founder animals were obtained and cre activity was analyzed by crossing the animals to R26R reporter mice. In this line, cre expression was restricted to cells at the midbrain-hindbrain boundary. The pattern of cre activity was not affected by doxycycline, indicating cre expression is not controlled the rtTA protein expressed from the Hoxb7 promoter.
(J:135242)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Hoxb7
(species not specified)
|
| |
|
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:135242 Kala K, et al., Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis. 2008 Jan;46(1):29-36 |
| All: |
1 reference(s) |
|
Analysis Tools
