Dlx5<tm1(cre/ERT2)Zjh> Targeted Allele Detail MGI Mouse (MGI:4355155)

Dlx5^{tm1(cre/ERT2)Zjh}
Targeted Allele Detail

Summary

Symbol:	Dlx5^{tm1(cre/ERT2)Zjh}
Name:	distal-less homeobox 5; targeted mutation 1, Z Josh Huang
MGI ID:	MGI:4355155
Synonyms:	Dlx5-CreER, Dlx5-CreERT2
Gene:	Dlx5 Location: Chr6:6877801-6882068 bp, - strand Genetic Position: Chr6, 2.83 cM
Alliance:	Dlx5^{tm1(cre/ERT2)Zjh} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:151755
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6
Project Collection:	Neuroscience Blueprint cre

Mutation
description

Allele Type:

Targeted (Inducible, Null/knockout, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Dlx5^{tm1(cre/ERT2)Zjh} expression driven by 1 gene

Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Dlx5 (distal-less homeobox 5) gene. This construct was electroporated into C57BL/6 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with white C57BL/6 mice to originate the colony. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background (N10)) to remove the neo selection cassette. (J:151755)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dlx5 (mouse) Summary of all recombinase alleles driven by Dlx5. Comparative matrix view of recombinase activities Alliance mouse Dlx5 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Dlx5 Mutation:	25 strains or lines available

References

Original:	J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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