Snord116<tm1Jbro> Targeted Allele Detail MGI Mouse (MGI:4356428)

Snord116^tm1Jbro
Targeted Allele Detail

Summary

Symbol:	Snord116^tm1Jbro
Name:	small nucleolar RNA, C/D box 116 cluster; targeted mutation 1, Jurgen Brosius
MGI ID:	MGI:4356428
Synonyms:	PWScr^5'LoxP
Gene:	Snord116 Location: unknown Genetic Position: Chr7, Syntenic

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:152022
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (No functional change, Not Applicable)
Mutation:		Insertion
		Mutation details: A cassette containing the 5' half of the HPRT mini-gene (driven by the Pgk promoter), a loxP site and a neomycin resistance gene (driven by the Polr2a promoter), was inserted 5' of Snord116. Mice with this allele don't display a discernible phenotype. When expressed from the maternal allele, this construct forces the expression of the snoRNA genes in the, normally maternally imprinted, Snord116 and Snord115 clusters. (J:152022)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Snord116 Mutation:	3 strains or lines available

Notes

Cre mediated recombination of this allele in combination with Ipw^tm1Jbro yields Del(7Ipw-Snord116)1Jbro.

References

Original:	J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
All:	3 reference(s)

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