About   Help   FAQ
Del(7Ipw-Snord116)1Jbro
Targeted Allele Detail
Summary
Symbol: Del(7Ipw-Snord116)1Jbro
Name: deletion, chr 7, Jurgen Brosius 1
MGI ID: MGI:4356431
Synonyms: Del1Jbro, PWScr-
Gene: Del(7Ipw-Snord116)1Jbro  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152022
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(7Ipw-Snord116)1Jbro involves 68 genes/genome features (Snhg14, Ipw, Gm23862 ...) View all
 
Mutation details: A cassette containing the 5' half of the HPRT mini-gene, a loxP site and a neomycin resistance gene was inserted 5' of Snord116 (Snord116tm1Jbro) and a cassette containing a puromycin resistance gene gene, a loxP site, and the 3' half of the HPRT mini-gene was inserted 3' of Ipw (Ipwtm1Jbro). Transient cre expression in ES cells deleted both genes/gene clusters. This region is termed the Prader-Willi Syndrome critical region (PWScr). (J:152022)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(7Ipw-Snord116)1Jbro Mutation:  0 strains or lines available
References
Original:  J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory