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Del(7Ipw-Snord116)1Jbro
Targeted Allele Detail
Summary
Symbol: Del(7Ipw-Snord116)1Jbro
Name: deletion, chr 7, Jurgen Brosius 1
MGI ID: MGI:4356431
Synonyms: Del1Jbro, PWScr-
Gene: Del(7Ipw-Snord116)1Jbro  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152022
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(7Ipw-Snord116)1Jbro involves 68 genes/genome features (Snhg14, Ipw, Gm23862 ...) View all
 
Mutation details: A cassette containing the 5' half of the HPRT mini-gene, a loxP site and a neomycin resistance gene was inserted 5' of Snord116 (Snord116tm1Jbro) and a cassette containing a puromycin resistance gene gene, a loxP site, and the 3' half of the HPRT mini-gene was inserted 3' of Ipw (Ipwtm1Jbro). Transient cre expression in ES cells deleted both genes/gene clusters. This region is termed the Prader-Willi Syndrome critical region (PWScr). (J:152022)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(7Ipw-Snord116)1Jbro Mutation:  0 strains or lines available
References
Original:  J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory