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Tg(KRT5-cre/ERT2)1Blh
Transgene Detail
Summary
Symbol: Tg(KRT5-cre/ERT2)1Blh
Name: transgene insertion 1, Brigid L Hogan
MGI ID: MGI:4358332
Synonyms: CK5-CreERT2, KRT5-CreERT2
Transgene: Tg(KRT5-cre/ERT2)1Blh  Location: unknown  
Alliance: Tg(KRT5-cre/ERT2)1Blh page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(KRT5-cre/ERT2)1Blh expression driven by 1 gene
 
Mutation details: The 6-kb human keratin 5 (KRT5) promoter drives a cre/ERT2 cassette. The cre/ERT2 is flanked by an intron and a polyadenylation sequence from the pCI mammalian expression vector. The construct was injected into fertilized zygotes. 11 founder lines were obtained, and 1 line that gave robust recombination in tracheal basal cells was propagated and maintained on a C57BL/6 x C3H background. (J:152012)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: KRT5 (human)
Summary of all recombinase alleles driven by KRT5.
 

Tumor Data
List all tumor models in MMHCdb carrying Tg(KRT5-cre/ERT2)1Blh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:152012 Rock JR, et al., Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12771-5
All:  30 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory