Nanos3<tm2.1(cre)Ysa> Targeted Allele Detail MGI Mouse (MGI:4358405)

Nanos3^{tm2.1(cre)Ysa}
Targeted Allele Detail

Summary

Symbol:	Nanos3^{tm2.1(cre)Ysa}
Name:	nanos C2HC-type zinc finger 3; targeted mutation 2.1, Yumiko Saga
MGI ID:	MGI:4358405
Synonyms:	Nanos3^Cre
Gene:	Nanos3 Location: Chr8:84900359-84911396 bp, - strand Genetic Position: Chr8, 40.45 cM
Alliance:	Nanos3^{tm2.1(cre)Ysa} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:136687
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Nanos3^{tm2.1(cre)Ysa} expression driven by 1 gene

Mutation details: The coding sequence for Cre recombinase, followed by the SV40 polyadenylation signal and a single frt site, resides in the first coding intron of the endogenous gene immediately following the ATG translation initiation codon. (J:136687)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nanos3 (mouse) Summary of all recombinase alleles driven by Nanos3. Alliance mouse Nanos3 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Nanos3 Mutation:	28 strains or lines available

References

Original:	J:136687 Suzuki H, et al., Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol. 2008 Jun 1;318(1):133-42
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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