Mir208atm1.1Dzw
Targeted Allele Detail
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| Symbol: |
Mir208atm1.1Dzw |
| Name: |
microRNA 208a; targeted mutation 1.1, Da-Zhi Wang |
| MGI ID: |
MGI:4359822 |
| Gene: |
Mir208a Location: Chr14:55186517-55186599 bp, - strand Genetic Position: Chr14, 28.0 cM
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| Alliance: |
Mir208atm1.1Dzw page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:152696
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: A DNA fragment from an intron of the Myh6 gene containing the micro RNA coding sequence was replaced with a floxed neo cassette via homologous recombination. Cre mediated recombination then removed the neo cassette leaving a single loxP site in the intron. PCR analysis confirmed the splice pattern of Myh6 was not disturbed. Northern blot analysis confirmed the absence of micro RNA expression in hearts from homozygous mice.
(J:152696)
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Generation of the Mir208atm1Dzw and Mir208atm1.1Dzw alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mir208a Mutation: |
2 strains or lines available
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| Original: |
J:152696 Callis TE, et al., MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009 Sep;119(9):2772-86 |
| All: |
1 reference(s) |
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Analysis Tools
