Pak4<tm2.1Amin> Targeted Allele Detail MGI Mouse (MGI:4360333)

Pak4^tm2.1Amin
Targeted Allele Detail

Summary

Symbol:	Pak4^tm2.1Amin
Name:	p21 (RAC1) activated kinase 4; targeted mutation 2.1, Audrey Minden
MGI ID:	MGI:4360333
Synonyms:	Pak4^f
Gene:	Pak4 Location: Chr7:28258244-28297609 bp, - strand Genetic Position: Chr7, 16.84 cM
Alliance:	Pak4^tm2.1Amin page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:152821
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 4. Germ line, cre mediated recombination removed the neo cassette leaving exons 2 through 4 floxed. (J:152821)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Pak4 Mutation:	94 strains or lines available

References

Original:	J:152821 Tian Y, et al., Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev. 2009 Aug-Sep;126(8-9):710-20
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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