About   Help   FAQ
Grik4tm1(cre)Ksak
Targeted Allele Detail
Summary
Symbol: Grik4tm1(cre)Ksak
Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Kenji Sakimura
MGI ID: MGI:4360478
Synonyms: Grik4-Cre, telencephalin-Cre
Gene: Grik4  Location: Chr9:42431708-42856296 bp, - strand  Genetic Position: Chr9, 23.8 cM
Alliance: Grik4tm1(cre)Ksak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152455
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Grik4tm1(cre)Ksak expression driven by 1 gene
 
Mutation details: Cre was inserted 3' to the translational start site and replaced the remainder of the first coding exon. Cre-driven expression is primarily in CA3 pyramidal cells of the hippocampus. (J:152455)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Grik4 (mouse)
Summary of all recombinase alleles driven by Grik4.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik4 Mutation:  48 strains or lines available
References
Original:  J:152455 Akashi K, et al., NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009 Sep 2;29(35):10869-82
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory