Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(MMTV-Erbb2*,-cre)1Mul
Name:	transgene insertion 1, William J Muller
MGI ID:	MGI:4361017
Synonyms:	MMTV-Neu-IRES-CRE, MMTV-NeuNDL2-5-IRES-Cre, MMTV-NIC, NIC
Transgene:	Tg(MMTV-Erbb2*,-cre)1Mul  Location: unknown
Alliance:	Tg(MMTV-Erbb2*,-cre)1Mul page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Inserted expressed sequence, Recombinase) Mutation:    Insertion   Tg(MMTV-Erbb2*,-cre)1Mul expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Erbb2 (MGI:95410)   Tg(MMTV-Erbb2*,-cre)1Mul expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note virus MMTV   Mutation details: A transgene was generated where an activated Erbb2 (Neu, oncogenic form NDL2-5) and cre recombinase (coupled by an internal ribosomal entry site (IRES)) are under control of the mammalian mammary tumor virus promoter (MMTV). (J:133325)

Activity:	Tissue activity of this recombinase allele
Driver:	MMTV (virus) Summary of all recombinase alleles driven by MMTV.

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2*,-cre)1Mul

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:133325 Ursini-Siegel J, et al., ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J. 2008 Mar 19;27(6):910-20
All:	39 reference(s)