Myo15a<tm1.1(cre)Ugds> Targeted Allele Detail MGI Mouse (MGI:4361284)

Myo15a^{tm1.1(cre)Ugds}
Targeted Allele Detail

Summary

Symbol:	Myo15a^{tm1.1(cre)Ugds}
Name:	myosin XVA; targeted mutation 1.1, Unite de Genetique des Deficits Sensoriels
MGI ID:	MGI:4361284
Synonyms:	Myo15-cre
Gene:	Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
Alliance:	Myo15a^{tm1.1(cre)Ugds} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:171218
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S1/SvImJ

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutation:

Insertion

Myo15a^{tm1.1(cre)Ugds} expression driven by 1 gene

Mutation details: A cre gene and FRT flanked hygromycin cassette were inserted at the transcriptional start site. Flp mediated recombination removed the hygromycin cassette. (J:171218)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myo15a (mouse) Summary of all recombinase alleles driven by Myo15a. Alliance mouse Myo15a gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Myo15a Mutation:	136 strains or lines available

References

Original:	J:171218 Caberlotto E, et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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