Nrcam<20884> Chemically induced Allele Detail MGI Mouse (MGI:4361555)

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Nrcam²⁰⁸⁸⁴
Chemically induced Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Nrcam²⁰⁸⁸⁴
Name:	neuronal cell adhesion molecule; 20884
MGI ID:	MGI:4361555
Gene:	Nrcam Location: Chr12:44375668-44648747 bp, + strand Genetic Position: Chr12, 20.71 cM
Alliance:	Nrcam²⁰⁸⁸⁴ page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: A C to T transition is located in exon 36 resulting in a premature stop codon (Q1033X). Semiquantitative PCR analysis indicates a decrease in mRNA levels. Western blot and immunohistochemical analysis failed to detect protein in homozygotes. (J:153042)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Nrcam Mutation:	87 strains or lines available

References

Original:	J:153042 Douglas DS, et al., Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis. J Neurosci. 2009 Sep 30;29(39):12089-100
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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