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Trp73tm1(cre)Agof
Targeted Allele Detail
Summary
Symbol: Trp73tm1(cre)Agof
Name: transformation related protein 73; targeted mutation 1, Andre M Goffinet
MGI ID: MGI:4365581
Synonyms: DeltaNp73-, DeltaNp73-Cre, DeltaNp73CreiresEGFP
Gene: Trp73  Location: Chr4:154140706-154224332 bp, - strand  Genetic Position: Chr4, 83.79 cM
Alliance: Trp73tm1(cre)Agof page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153209
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Trp73tm1(cre)Agof expression driven by 1 gene
 
Mutation details: A cre recombinase sequence was targeted to the Trp73 locus in frame at the alternative start codon located in exon 3' (where transcription of the DeltaNp73 isoform is initiated), inactivating the DeltaNp73 isoform and leaving the primary Trp73 transcript (TAp73) unaffected. The cre sequence is followed by an internal ribosomal entry site (IRES) and an EGFP coding sequence. The targeting construct that was used also contains an FRT-flanked Neo cassette and a diphtheria toxin A (DTA) negative selection cassette. (J:153209)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Trp73 (mouse)
Summary of all recombinase alleles driven by Trp73.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp73 Mutation:  46 strains or lines available
References
Original:  J:153209 Tissir F, et al., DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16871-6
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory