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Lhx6tm1(cre/ERT2)Zjh
Targeted Allele Detail
Summary
Symbol: Lhx6tm1(cre/ERT2)Zjh
Name: LIM homeobox protein 6; targeted mutation 1, Z Josh Huang
MGI ID: MGI:4365737
Synonyms: Lhx6-CreER, Lhx6-CreERT2, Lhx6 delta neo
Gene: Lhx6  Location: Chr2:35971965-35995420 bp, - strand  Genetic Position: Chr2, 24.17 cM
Alliance: Lhx6tm1(cre/ERT2)Zjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151755
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Project Collection: Neuroscience Blueprint cre
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Lhx6tm1(cre/ERT2)Zjh expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Lhx6 (LIM homeobox protein 6) gene. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to remove the neo selection cassette. These Lhx6-CreERT2 mice were subsequently bred with wildtype siblings and/or wildtype C57BL/6 mice for at least one generation (and the FLPe transgene was removed) (J:151755)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lhx6 (mouse)
Summary of all recombinase alleles driven by Lhx6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 60 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhx6 Mutation:  27 strains or lines available
References
Original:  J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory