Tg(Slc6a4-cre/ERT2)EZ13Gsat
Transgene Detail
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| Symbol: |
Tg(Slc6a4-cre/ERT2)EZ13Gsat |
| Name: |
transgene insertion EZ13, GENSAT Project at Rockefeller University |
| MGI ID: |
MGI:4367233 |
| Synonyms: |
Founder Line EZ13, Tg(Slc6a4-cre/Esr1)13Gsat |
| Transgene: |
Tg(Slc6a4-cre/ERT2)EZ13Gsat Location: unknown
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| Alliance: |
Tg(Slc6a4-cre/ERT2)EZ13Gsat page
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| Strain of Origin: |
FVB/N
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| Project Collection: |
GENSAT
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(Slc6a4-cre/ERT2)EZ13Gsat expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Slc6a4 (MGI:96285) |
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Mutation details: This transgene contains the coding sequence for the Cre-ERT2 fusion protein, followed by a polyadenylation signal, inserted into a mouse genomic artificial chromosome (BAC) at the ATG transcription initiation codon of the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gene so that expression of the tamoxifen-activated recombinase is driven by the regulatory sequences of the mouse gene. ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands.
(J:100256, J:145100)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Slc6a4
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:100256 The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY), MGI download of GENSAT transgene data. Database Download. 2005; |
| All: |
7 reference(s) |
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Analysis Tools
